Endoplasmic reticulum stress plays an important role in amyotrophic lateral sclerosis (Commentary on Prell et al.)
نویسندگان
چکیده
منابع مشابه
[Commentary on the Article 'Healing of Amyotrophic Lateral Sclerosis: A Case Report' by Mangelsdorf et al.]
In addition, given the relatively long time lapses between the removal of the amalgam fillings in 1999, the herpes zoster-associated encephalitis in 2004, and the beginning of the symptoms in 2012, 1 year after a divorce, it does not seem very probable to me that mercury was the main cause of PMA or ALS in this patient, but perhaps the osteitis in the jaw in combination with already partially d...
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The occurrence of endoplasmic reticulum (ER) stress in the sporadic form of amyotrophic lateral sclerosis (ALS) is unknown, despite it has been recently documented in experimental models of the familial form. Here we show that spinal cord from patients with sporadic ALS showed signs of ER stress, such as increased levels of ER chaperones such as protein-disulfide isomerase, and increased phosph...
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Detergent-resistant, ubiquitinated and hyperphosphorylated Tar DNA binding protein 43 (TDP-43, encoded by TARDBP) neuronal cytoplasmic inclusions are the pathological hallmark in ∼95% of amyotrophic lateral sclerosis and ∼60% of frontotemporal lobar degeneration cases. We sought to explore the role for the heat shock response in the clearance of insoluble TDP-43 in a cellular model of disease a...
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Abstract Lead is a heavy metal that affects many organs such as nervous system, liver, and kidney. The most important affected organ is central nervous system. The present study reported a case similar to Amyotrophic lateral sclerosis (ALS) due to lead exposure in an opium addicted person. The patient complaint was the weakness of upper and lower limbs in addition to the unsteadiness of gait...
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Editor's Note: These short reviews of a recent paper in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see Review of Yang et al. Amyotrophic lateral sclerosis (ALS) is a devastating...
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ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2012
ISSN: 0953-816X
DOI: 10.1111/j.1460-9568.2012.08063.x